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Alexander de Luna (CV)

Assistant Professor

Alexander de Luna (CV)


Assistant Professor


Genetic Systems Biology


adeluna a langebio.cinvestav.mx


52 (462) 166 3000 ext. 3069


We are are interested in understanding how how genes, the environment, and their interactions influence complex cellular phenotypes such as proliferation capacity, response to stress, and aging. We are also interested in the evolution of such traits. We use yeast cells, robots, and computers for our research.


1997 BSc in Biology from Universidad de Guadalajara (Mexico)
2002 PhD in Biomedical Sciences from UNAM (Mexico) at IFC
2004-2008 Postdoc at Harvard Medical School (USA) with Roy Kishony


2005 Pew Fellow in the Biomedical Sciences
2012 TWAS Young Affiliated Member
2014 Canifarma Mexico Award, 2nd place, Basic Biomedical Research
2016 Member of the ACAL Latin American Academy of Science



E Garay, SE Campos, J González de la Cruz, AP Gaspar, A Jinich, A DeLuna. (2014) High-resolution profiling of stationary phase survival reveals yeast longevity factors and their genetic interactions. PLoS Genetics 10(2):e1004168. [link]

18. G Diss, D Ascencio, A DeLuna, CR Landry. (2014) Molecular mechanisms of paralogous compensation and the robustness of cellular networks. J Exp Zool B Mol Dev Evol 322(7):488-499 [link]

M Razo-Mejia, JQ Boedicker, D Jones, A DeLuna, JB Kinney, R Phillips. (2014) Comparison of the theoretical and real-world evolutionary potential of a genetic circuit. Phys Biol 11(2):026005 [link]

16. L Miron, A Mira, V Rocha-Ramirez, P Belda-Ferre, R Cabrera-Rubio, J Folch-Mallol, R Cardenas, A DeLuna, AL Hernandez, E Maya, JE Schondube. (2014) Gut bacterial diversity of the house sparrow (Passer domesticus) inferred by 16S rRNA sequence analysis. Metagenomics 3:235853

15. A DeLuna, M Springer, MW Kirschner, R Kishony. (2010) Need-based up-regulation of protein levels in response to deletion of their duplicate genes.PLoS Biology 8(3):e1000347. [link]

14. A DeLuna, K Vetsigian, N Shoresh, M Hegreness, M Cólon-Gonzalez, S Chao, R Kishony. (2008) Exposing the fitness contribution of duplicated genes.Nature Genetics 40(5):676. [link]

13. L Delaye, A DeLuna, A Lazcano, A Becerra. (2008) The origin of a novel gene through overprinting in Escherichia coli. BMC Evolutionary Biology 8:31.[link]

12. D Segrè, A DeLuna, GM Church, R Kishony. (2005) Modular epistasis in yeast metabolism. Nature Genetics 37(1):77-83. [link]

11. H Quezada C Aranda, A DeLuna, H Hernández, ML Calcagno, A Marín-Hernández, A González. Specialization of the paralogue LYS21 determines lysine biosynthesis under respiratory metabolism in Saccharomyces cerevisiae. (2008) Microbiology-SGM 154(6):1656.

10. C Aranda, M Colón, C Ishida, L Riego, A DeLuna, L Valenzuela, J Herrera, A González. (2006) Gcn5p contributes to the bidirectional character of the UGA3–GLT1 yeast promoter. Biochem Bioph Res Co 348(3):989.

9. C Ishida, C Aranda, L Valenzuela, L Riego, A DeLuna, S Zonszein, F Recillas-Targa, A González. (2006) The UGA3-GLT1 intergenic region ofSaccharomyces cerevisiae: A model to study the combinatorial action of Gln3p, Gcn4p and chromatin organization on the transcriptional activity of a bidirectional promoter. Molecular Microbiology 59(6):1790-1806.

8. A DeLuna, H Quezada, A Gomez-Puyou, A Gonzalez. (2005) Asparaginyl Deamidation in Two Glutamate Dehydrogenase Isoenzymes from Saccharomyces cerevisiae. Biochem Bioph Res Co 328(4):1083-1090.

7. A Avendaño, L Riego, A DeLuna, C Aranda, M Vázquez-Acevedo, F Recillas-Targa, L Valenzuela, S Zonszein, A González. (2005) SWI/SNF-GCN5-dependent chromatin remodeling determines induced expression of GDH3, one of the paralogous genes responsible for ammonium assimilation and glutamate biosynthesis in Saccharomyces cerevisiae. Molecular Microbiology 57(1):291-305.

6. CA Guerrero, C Aranda, A DeLuna, P Filetici, L Riego, VH Anaya, González. (2005) Salt-dependent expression of ammonium assimilation genes in the halotolerant yeast Debaryomyces hansenii. Current Genetics 47(3):163-171.

5. L Alba-Lois, C Segal, B Rodarte, V Valdés-López, A DeLuna, R Cárdenas. (2004) NADP-glutamate dehydrogenase activity is increased under hyperosmotic conditions in the halotolerant yeast Debaryomyces hansenii. Current Microbiology 48 (1):68-72.

4. E Sosa, C Aranda, L Riego, L Valenzuela, A DeLuna, JM Cantu, A Gonzalez. (2003) Gcn4 negatively regulates expression of genes subjected to nitrogen catabolite repression. Biochem Bioph Res Co 310(4):1175-1180.

3. L Riego, A Avendaño, A DeLuna, E Rodríguez, A González. (2002) GDH1 expression is regulated by GLN3, GCN4 and HAP4 under respiratory growth.Biochem Bioph Res Co 293(1):79–85.

2. A DeLuna, A Avendaño, L Riego, A González. (2001) NADP-glutamate dehydrogenase isoenzymes of Saccharomyces cerevisiae. Purification, enzyme kinetics and physiological roles. Journal of Biological Chemistry 276(47):43775–43783.

1. A Avendaño, A DeLuna, L Valenzuela, H Olivera, A González. (1997) GDH3 encodes a glutamate dehydrogenase isozyme, a previously unrecognized route for glutamate biosynthesis in Saccharomyces cerevisiae. Journal of Bacteriology 197(17):5594–5597.

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