English | Español
cinvestav

Alexander de Luna (CV)

Assistant Professor
 

Alexander de Luna (CV)

Position

Assistant Professor
 

Group

Genetic Systems Biology
 

E-mail

alexander.deluna a cinvestav.mx
 

Phone

52 (462) 166 3000 ext. 3069

Research

We are are interested in understanding how how genes, the environment, and their interactions influence complex cellular phenotypes such as proliferation capacity, response to stress, and aging. We are also interested in the evolution of such traits. We use yeast cells, robots, and computers for our research.

Education

1997 BSc in Biology from Universidad de Guadalajara (Mexico)
2002 PhD in Biomedical Sciences from UNAM (Mexico) at IFC
2004-2008 Postdoc at Harvard Medical School (USA) with Roy Kishony

Awards

2005 Pew Fellow in the Biomedical Sciences
2012 TWAS Young Affiliated Member
2014 Canifarma Mexico Award, 2nd place, Basic Biomedical Research
2016 Aida Weiss PUIS-UNAM Award, Research
2016 Member of the ACAL Latin American Academy of Sciences

Publications

Pubmed

Scholar

*SE Campos, E Garay, JA Avelar-Rivas, A Juárez-Reyes, A DeLuna. Genome-wide mechanisms of lifespan extension by dietary restriction. BioRxiv doi.org/10.1101/126797 (2017)

*C Valadez-Cano, R Olivares-Hernández, O Resendis-Antonio, A DeLuna, L Delaye. Positive selection drove metabolic specialization of the chromatophore in Paulinella chromatophora. BMC Evolutionary Biology 17:99. (2017)

*D Ascencio, S Ochoa, L Delaye, A DeLuna. Increased rates of protein evolution followed by asymmetric deceleration after the whole-genome duplication in yeasts. BMC Evolutionary Biology 17:40. (2017)

*J Ponce-Rojas, A Yañez-Falcon, F Jaimes-Miranda, E Garay, A DeLuna, S Funes. αβ’-NAC cooperates with Sam37 to mediate early stages of mitochondrial protein import. FEBS Journal 284(5):814-30. (2017)

*G Guerrero-Serrano, L Castanedo, GR Cristobal-Mondragón, J Montalvo-Arredondo, L Riego-Ruiz, A DeLuna, A De Las Peñas, I Castaño, MR Calera, R Sánchez-Olea. Npa3/ScGpn1 carboxy-terminal domain is dispensable for cell viability and RNA polymerase II nuclear targeting but critical for microtubule stability. Biochemica et Biophysica Acta 1864(3):451-62. (2017)

*JL Aguilar-Lopez, R Laboy, F Jaimes-Miranda, E Garay, A DeLuna, S Funes. Slm35 links mitochondrial stress response and longevity through TOR signaling pathway. Aging 8(12):3255-71. (2016)

*A Espinosa-Cantú, D Ascencio, F Barona-Gómez, A DeLuna. Gene duplication and the evolution of moonlighting proteins. Frontiers in Genetics 6:227. (2015)

*K Voordeckers, J Kominek, A Das, A Espinosa-Cantú, D De Maeyer, A Arslan, M Van Pee, E van der Zande, W Meert, Y Yang, B Zhu, K Marchal, A DeLuna, V Van Noort, R Jelier, KJ Verstrepen. Adaptation to high ethanol reveals complex evolutionary pathways. PLoS Genetics 11(11):e1005635. (2015)

*G López, H Quezada, M Duhne, J González, M Lezama, M El-Hafidi, M Colón, X Martínez de la Escalera, MC Flores-Villegas, C Scazzocchio, A DeLuna, A González. Diversification of paralogous alfa-iosopropylmalate synthases by modulation of feedback control and hetero-oligomerization in Saccharomyces cerevisiae. Eukaryotic Cell 14(6):564-77. (2015)

*E Garay, SE Campos, J González de la Cruz, AP Gaspar, A Jinich, A DeLuna. High-resolution profiling of stationary phase survival reveals yeast longevity factors and their genetic interactions. PLoS Genetics 10(2):e1004168. (2014)

*L Mirón, A Mira, V Rocha-Ramírez, P Belda-Ferre, R Cabrera-Rubio, J Folch-Mallol, R Cardénas-Vázquez, A DeLuna, AL Hernández, E Maya-Elizarrarás, J Schondube. Gut bacterial diversity of the House Sparrow (Passer domesticus) inferred by 16S rRNA sequence analysis. Metagenomics 3:235853. (2014)

*M Razo-Mejia, JQ Boedicker, D Jones, A DeLuna, JB Kinney, R Phillips. Comparison of the theoretical and real-world evolutionary potential of a genetic circuit. Physical Biology 11(2):026005. (2014)

*G Diss, D Ascencio, A DeLuna, CR Landry. Molecular mechanisms of paralogous compensation and the robustness of cellular networks. J Exp Zool B Mol Dev Evol 322(7):488-99. (2013)

*D Ascencio, A DeLuna. Genetic Redundancy. In: Encyclopedia of Systems Biology (W. Dubitzky, O. Wolkenhauer, K. Cho & H. Yokota, Eds.), ISBN: 978-1-4419-9862-0, Springer Science Business Media, pp 824–827. (2013)

*A DeLuna, M Springer, MW Kirschner, R Kishony. Need-based up-regulation of protein levels in response to deletion of their duplicate genes. PLoS Biology 8(3):e1000347. (2010)

*L Delaye, A DeLuna, A Lazcano, A Becerra. The origin of a novel gene through overprinting in Escherichia coli. BMC Evolutionary Biology 8:31. (2008)

*A DeLuna, K Vetsigian, N Shoresh, M Hegreness, M Colon-Gonzalez, S Chao, R Kishony. Exposing the fitness contribution of duplicated genes. Nature Genetics 40(5): 676-681. (2008)

*H Quezada C Aranda, A DeLuna, H Hernández, ML Calcagno, Á Marín-Hernández, A González. Specialization of the paralogue LYS21 determines lysine biosynthesis under respiratory metabolism in Saccharomyces cerevisiae. Microbiology-SGM 154:1656-1667. (2008)

*C Aranda, M Colon, C Ishida, L Riego, A DeLuna, L Valenzuela, J Herrera, A Gonzalez. Gcn5p contributes to the bidirectional character of the UGA3-GLT1 yeast promoter. Biochemical and Biophysical Research Communications 348(3):989-996. (2006)

*C Ishida, C Aranda, L Valenzuela, L Riego, A DeLuna, F Recillas-Targa, P Filetici, R Lopez-Revilla, A Gonzalez. The UGA3-GLT1 intergenic region constitutes a promoter whose bidirectional nature is determined by chromatin organization in Saccharomyces cerevisiae. Molecular Microbiology 59(6):1790-1806. (2006)

*A DeLuna, H Quezada, A Gomez-Puyou, A Gonzalez. Asparaginyl Deamidation in Two Glutamate Dehydrogenase Isoenzymes from Saccharomyces cerevisiae. Biochemical and Biophysical Research Communications 328(4):1083-1090. (2005)

*D Segrè, A DeLuna, GM Church, R Kishony (2005). Modular epistasis in yeast metabolism. Nature Genetics 37(1):77-83

*A Avendaño, L Riego, A DeLuna, C Aranda, M Vázquez-Acevedo, F Recillas-Targa, L Valenzuela, S Zonszein, A González. SWI/SNF-GCN5-dependent chromatin remodeling determines induced expression of GDH3, one of the paralogous genes responsible for ammonium assimilation and glutamate biosynthesis in Saccharomyces cerevisiae. Molecular Microbiology 57(1):291-305. (2005)

*CA Guerrero, C Aranda, A DeLuna, P Filetici, L Riego, VH Anaya, A Gonzélez. Salt-dependent expression of ammonium assimilation genes in the halotolerant yeast Debaryomyces hansenii. Current Genetics 47(3):163-171. (2005)

*L Alba-Lois, C Segal, B Rodarte, V Valdés-López, A DeLuna, R Cárdenas. NADP-glutamate dehydrogenase activity is increased under hyperosmotic conditions in the halotolerant yeast Debaryomyces hansenii. Current Microbiology 48 (1):68-72. (2004)

*E Sosa, C Aranda, L Riego, L Valenzuela, A DeLuna, JM Cantu, A Gonzalez. Gcn4 negatively regulates expression of genes subjected to nitrogen catabolite repression. Biochemical and Biophysical Research Communications 310(4):1175-1180. (2003)

L Riego, A Avendaño, A DeLuna, E Rodríguez, A González. GDH1 expression is regulated by GLN3, GCN4 and HAP4 under respiratory growth. Biochemical and Biophysical Research Communications 293(1):79–85. (2002)

*A DeLuna, A Avendaño, L Riego, A González. NADP-glutamate dehydrogenase isoenzymes of Saccharomyces cerevisiae. Purification, enzyme kinetics and physiological roles. Journal of Biological Chemistry 276(47):43775–43783. (2001)

*A Avendaño, A DeLuna, L Valenzuela, H Olivera, A González. GDH3 encodes a glutamate dehydrogenase isozyme, a previously unrecognized route for glutamate biosynthesis in Saccharomyces cerevisiae. Journal of Bacteriology 197(17):5594–5597. (1997)

Te invitamos a actualizar tu navegador!


 

 

cerrar

 

 

* Si usas Internet Explorer asegúrate de tener la versión más actualizada!