I did a major in Biology at the Autonomous University of the State of Mexico (UAEMex) and obtained my bachelor degree working on the expression of the interleukin 6 receptor alpha in Schwann cells during rat sciatic nerve regeneration. Later I did a PhD in Zoology at the University of Oxford where I studied neural helix-loop-helix genes of the brook lamprey Lampetra planeri and regulation of their expression by the Notch signaling pathway in the lamprey spinal cord. After my PhD at Oxford, I did a 1-year postdoctoral research project in France on the retinoic acid pathway in amphioxus at the transcriptome level. Overall, I study the evolution of the chordate nervous system.
Project at LANGEBIO
In this project I will study different molecular aspects of the development and regeneration of the axolotl (Ambystoma mexicanum) spinal cord at its posterior end. This includes the study of the retinoic acid (RA), FGF, and WNT signaling pathways, as well as important developmental genes of the homeobox gene family and regulation of their expression by RA, FGF and WNT signalling. In addition, I will characterize the axolotl Hox clusters and the epigenetic regulation exerted on the expression of Hox genes that may have a role in axolotl spinal cord regeneration. These studies will be complemented with the characterization of Hox clusters in Mexican Bolitoglossine salamanders.
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