Human evolutionary and population genomics

We use genomic data and computational tools to understand demographic and evolutionary processes that have given place to the genetic human diversity, both in indigenous groups around the world and cosmopolitan populations derived from miscegenation.

We analyze the patterns of genetic mixing on genomes of multiethnic origins to infer the time and manner of recent human migrations and other demographic events that affect the distribution of genetic variants, with emphasis on those with medical and functional relevance.

Research lines:

• Population genetics of Latin-American populations.
• Medical genomics.
• Genetic anthropology.
• Genomic services. (http://labsergen.langebio.cinvestav.mx/en/)

Recent projects:

• “Human functional genomics of native Americans in Latin America”. ICGEB (2016-2018).
• “Mexican biobank: developing capacities for data science in genomic medicine of Mestizo populations”. FONCICYT (2016-2019).
• “Genomic and evolutionary analysis of functional variants in indigenous populations of Mexico”. CONACYT-Basic Science (2016-2018).

Most relevant publications:

• 1. Genomic insights into the origin and diversification of late maritime hunter-gatherers from the Chilean Patagonia. PNAS, 2018. 86, 201715688.
• 2. Genomic Insights into the Ancestry and Demographic History of South America. PLOS Genetics. 2015 Dec 4;11(12):e1005602. PMID: 26636962.
• 3. The 1000 Genomes Project Consortium, A global reference for human genetic variation. Nature 2015; 526(7571), 68–74.
• 4. Genomic evidence for the Pleistocene and recent population history of Native Americans. Science, 2015 Aug 21;349(6250):aab3884. PMID: 26198033.
• 5. The genetics of Mexico recapitulates Native American substructure and affects biomedical traits. Science 2014; 344(6189): 1280–1285. PMID: 24926019.

Recent publications:

To access all publications, click the following links: