Dr. Cei Abreu Goodger
GRUPOS DE TRABAJO
Our interests lie within the realm of gene regulation, with a focus on RNA-based regulatory mechanisms.
We develop computational approaches to study the functional and evolutionary effects that microRNAs have on gene expression. Highly conserved miRNAs are particularly interesting in this regard, since they tend to affect larger numbers of transcripts, even though the majority of individual target sites are not highly conserved. By comparing experiments performed in different species or reconstructing ancestral sequences, we can study the evolution of miRNA-target networks across various evolutionary distances.
We are also interested in studying small RNAs that can be transferred between cells and even between species. Recently many extra-cellular small RNAs, including microRNAs, have been discovered, usually within exosomes. A few cases of RNA-based communication between species have been documented, but many questions remain.
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