Therapeutic peptides

doctor

More about us:

Dr. Fabien Plisson

Principal Investigator

In our group, we are interested in the discovery and design of peptide-based drugs. Peptides offer advantageous pharmacological characteristics, we design peptides for unmet medical needs and against agrochemical pests. We take advantage of knowledge discovery in databases (KDD) and scientific literature to better understand the relationships between structures, functions and the evolution of these peptides. We develop innovative methodologies including 'machine learning’ algorithms to accelerate the drug discovery and design process and support these studies.

Research lines:

  • Discovery of bioactive peptides from Mexican (venomous) species using transcriptomics and / or proteomics.
  • Design of peptides for therapeutic, biotechnological and biomaterial applications.
  • Development of computational tools to harness natural products.

Recent projects:

  • “Caracterización estructural y funcional de venenos de hormigas: un enfoque multidisciplanario”. Convocatoria de Investigación Científica Básica 2017-2018, Comisión del Área de Química.
  • “Diseño de novo péptidos antimicrobianos usando Deep Learning”. CINVESTAV 12a Convocatoria interna para asignación de recursos en el clúster híbrido de supercómputo Xiuhcoatl.
  • “Diseño de análogos hiperestables del péptido LL-37 contra la tuberculosis humana y bovina”. CINVESTAV Unidad de Genómica Avanzada LANGEBIO Convocatoria Interna.

Most relevant publications:

Recent publications:

To access all publications, click the following links:


work team


Dr. Fabien Plisson

Principal Investigator

fabien.plisson@cinvestav.mx

M. Sc. Mariana del Carmen Aguilera Puga

PhD student in Plant Biotechnology

"Discovery of membranolytic antimicrobial peptides in plants"

M. Sc. Rafael González Castro

PhD student in Plant Biotechnology

"Design of hyperstable peptides against the formation of biofilms (in codirection with Dr. Miguel Gómez Lim)"

Cristina Martínez Hernández

Master’s student in Plant Biotechnology

"Design of effective and selective anticancer peptides (in codirection with Dr. Miguel Gómez Lim)"

Emmanuel Ricardo Lagunas Ocampo

Master’s student in Plant Biotechnology

"Design of new ion channel blockers"